Angelo Vertti, 18 de setembro de 2022

The last two decades have witnessed a major revolution in the field of immunology. However, anti-vaccine groups in more affluent countries are putting society at risk for a return of the serious illnesses that had almost been forgotten, such as diphtheria and tetanus183, with an increase in measles in unvaccinated people at epidemic levels, thus negating many of the advances made over many years. CAS Advances in Immunology must find itself among the most active volumes in the libraries of our universities and institutions. 10, 112 (2019). Winter, G. Harnessing evolution to make medicines (Nobel Lecture). Nat. Taams, L. S. Neuroimmune interactions: how the nervous and immune systems influence each other. Martin, N. T. et al. The main focus of this review is ILCs. Scepanovic, P. et al. SJR is a measure of scientific influence of journals that accounts for both the number of citations received by a journal and the importance or prestige of the journals where such citations come from It measures the scientific influence of the average article in a journal, it expresses how central to the global scientific discussion an average . Article Search - Elsevier Science 328, 17051709 (2010). Adachi, K. et al. Nat. Virus-based therapy was introduced in the 1990s with the use of adenovirus, but only in recent years has it been used in practice in the clinic. Suicide gene therapy to increase the safety of chimeric antigen receptor-redirected T lymphocytes. Alexandre, D. & Lefranc, M. P. The human /+ and /+ T cells: a branched pathway of differentiation. Med. There are several aspects of the COVID-19 pathogeny that suggest an overreaction of the immune system in severely ill patients, with increased levels of inflammatory cytokines such as IL-6, IL-1 and others (creating the so-called cytokine storm), together with blood lymphopenia and CD8 T cell and NK cell exhaustion. Immunotherapy using microorganisms or their components in vaccines was first practiced centuries ago; soluble substances such as poly- and monoclonal antibodies, as well as cytokines, have been used for many years, but recently, cellular immunotherapy has emerged in clinical practice. Lysis of natural killer-resistant fresh solid tumor cells by interleukin 2-activated autologous human peripheral blood lymphocytes. J. Med. Since its discovery, MHC has emerged as the most polymorphic gene locus in eukaryotes with 24093 HLA and related alleles, more than 362709 nucleotide variants reported in the Individual-Participant DataInternational ImMunoGeneTics/Human Leukocyte Antigen (IPDIMGT/HLA) work group database (https://www.ebi.ac.uk/ipd/imgt/hla/), release 3.39.0, 2020/01/20149. Immunol. Carriers of toxins, pro-drugs, enzymes, and radioactive elements. PubMed Pannemans, K., Hellings, N. & Stinissen, P. Therapeutic vaccines for autoimmune diseases. & Kabashima, K. Anti-PD-1 and Anti-CTLA-4 therapies in cancer: mechanisms of action, efficacy, and limitations. The transcription factor GATA-3 is necessary and sufficient for Th2 cytokine gene expression in CD4 T cells. 3, 77103 (2019). 10, 864871 (2009). New insights into the biology of CD8 regulatory T cells. Nat. 136, 171175 (1977). ), it is being used most expansively in the cancer field. Allergen-specific immunotherapy (AIT) aims to modulate the immune system against an allergen, thus modifying the natural course of the allergic disease and conferring long-lasting benefits201. Drug Discov. Immunol. 10, 405 (2019). 140, 120 (2018). J. Leukoc. J. Exp. 6, 3944 (2009). Several companies are currently developing human antibodies using these and new technologies (reviewed in225,227,233,234). 12, 45 (2014). Therapeutic cancer vaccines. have met with limited success188, which indicates that this type of therapy is much more complex than initially anticipated. A. et al. Year: Impact Factor (IF) Total Articles: Total Cites: 2021 (2022 update) 5.324-3160 . The data indicate that the therapy is well tolerated and has led to increased patient survival in some trials. Immunol. High-dose cholecalciferol supplementation significantly increases peripheral CD4+ Tregs in healthy adults without negatively affecting the frequency of other immune cells. Pasteur 4, 384426 (1890). Annual Review of Immunology | Home Natl Acad. Pagani, M. et al. Innate and adaptive nasal mucosal immune responses following experimental human pneumococcal colonization. Phage libraries for generation of clinically useful antibodies. According to the last 2022 report 485 different genetic defects causing IEI are known (55 novel comparying to 2019 report), categorized as previously into 10 groups and published as phenotypical classification as well. Cancer Res. for the treatment of various cancers and autoimmune diseases and the manipulation of the immune system through vaccines for the prevention and treatment of infectious and allergic diseases (Fig. USA. Ehrlich, P. Ueber den jetzigen stand der karzinomforschung. & Rudensky, A. Y. Tissue residency of innate lymphoid cells in lymphoid and nonlymphoid organs. Nat. Frontiers in Immunology portrays how advances of scientific knowledge and technology may translate into novel approaches to diagnosis and treat immune disorders, both in animal and cellular models and in humans. Immunol. Eur. 338, 640644 (1998). & Prez-Tapia, S. M. Phage display libraries for antibody therapeutic discovery and development. The development of many different mAbs has enabled the identification of new molecules and the development of more accurate diagnostic approaches; specific, fast and inexpensive technologies; processes for the purification/concentration of compounds; and better and more specific therapy. Immunol. In the meantime, to ensure continued support, we are displaying the site without styles Hepatol. As asthma and other allergic-associated traits could be present in patients without allergies, some researchers performed GWAS analysis on cohorts of patients who had high levels of allergen-specific immunoglobulin E (IgE) or a positive skin prick test. 137, 351357 (2016). It is clear that certain viruses and bacteria play roles in cancer development. CAS Nature 535, 7584 (2016). Since their initial use, these interferon species have been approved for many other diseases, including chronic hepatitis B and C, lymphoma, advanced melanoma, and as adjuvants together with other therapies for several types of cancers254,255. Porter, D. L., Levine, B. L., Kalos, M., Bagg, A. Mosmann, T. R. & Sad, S. The expanding universe of T-cell subsets: Th1, Th2 and more. 216, 728742 (2019). Comparisons of therapeutic efficacy and safety of ipilimumab plus GM-CSF versus ipilimumab alone in patients with cancer: a meta-analysis of outcomes. Front. Jiang, X. R. et al. Rev. Drugs 76, 147154 (2016). Abrahamsson, T. R. et al. Proc. Immunol. Rev. The great advances in immunology in recent years make this field one of the most rapidly growing in biological sciences. Lantelme, E., Mantovani, S., Palermo, R ., Campanelli, B., Sallusto, F. & Giachino, C. Kinetics of GATA-3 gene expression in early polarizing and committed human T cells. Moreover, the protection exerted by maternal antibodies transferred through the placenta during pregnancy against some pathogens interferes with the development of the newborns own immune response. Wout, J. W., Poell, R. & Furth, R. The rof BCG/PPD-activated macrophages in resistance against systemic candidiasis in mice. The journal serves as a forum for new concepts and advances in basic, translational, and clinical cancer immunology and immunotherapy. Successful adoptive transfer and in vivo expansion of haploidentical T cells. Associate Editors:K. Frank AustenHarvard Medical School, Boston, Massachusetts, USATasuku HonjoKyoto University, Kyoto, JapanFritz MelchersUniversity of Basel, Basel, SwitzerlandHidde PloeghMassachusetts Institute of Technology, Massachusetts, USAKenneth M. MurphyWashington University, St. Louis, Missouri, USA, Copyright 2023 Elsevier, except certain content provided by third parties, Cookies are used by this site. MAbs 8, 11771194 (2016). 58, 809822 (2009). Exp. 3, 219227 (2015). the science community has also noted that review articles typically are more citable than research articles.Here you can check the journal performance trends based on last 20 years of data, also check the latest journal citation reports . Nat. 3, e26 (2007). Optimal model establishment of whole-process management data for CAR-T therapy in Chinahow should this be done? Germ-free mice are characterized by atrophy of Peyers patches with few germinal centers and isolated lymphoid follicles, a lower number of B, T, and dendritic cells and a decreased level of immunoglobulins, particularly IgA and IgG118. Immunol. Adipose-Resident Group 1 innate lymphoid cells promote obesity-associated insulin resistance. Immunol. Muramatsu, D. et al. Cancer J. J. Immunol. Therapeutic Advances in Vaccines and Immunotherapy: SAGE Journals Biotechnol. Researchers are working on genetic (RNA, DNA) vaccines because they have great advantages, including no requirement for growing a pathogen. The lack of efficacy on other tests was probably due to the presence of immunosuppressive factors in the tumor environment. PubMed Central Immune Netw. Blood 135, 656667 (2020). 16, 149163 (2016). Development of immune checkpoint therapy for cancer. Br. Buurman, D. J. et al. Rev. Sci. Hum. Immunity publishes the most important advances in immunology research. J. Med. Cell Rep. Med. Impact factor: Two-year: 5.426 (2021 Journal Citation Reports) Five year: 6.173 (2021 Journal Citation Reports) Citations: The JI is cited more than any other immunology journal (2021 Journal Citation Reports) Cited Half-Life: 12.7 years (2021) Number of research articles published/year: 519 (2021) Number of pages published/year: 6,129 (2021) Med. JV and SM acknowledge contracts from Programa INTERREG V-A Espaa-Portugal (POCTEP) 2014-2020 and Retencin de Talento Investigador from the University of Vigo, respectively. Nanomaterials. & Hughes, C. C. W. Of mice and not men: differences between mouse and human immunology. J. Clin. IL-2 was identified in 1976 as a growth factor for T lymphocytes, and soon after Dr. Rosenberg started to use it in antitumoral therapy250,251. Cell. Vaccines 7, 169 (2019). 25, 17691781 (2017). Proliferating dendritic cell progenitors in human blood. Otsuka, M., Egawa, G. & Kabashima, K. Uncovering the mysteries of langerhans cells, inflammatory dendritic epidermal cells, and monocyte-derived Langerhans cell-like cells in the epidermis. Meta-analysis of Immunochip data of four autoimmune diseases reveals novel single-disease and cross-phenotype associations. These polymorphisms are mapped within the MHC (HLA-DQB1*03, HLA-DR1, or HLA-DP1), natural killer cell immunoglobulin-like receptors 1 and 4 (KIR3DL1 and KIR2DS4) and natural killer lectin-like receptor D1 (KLDR-1)133. 5. PLoS Pathog. Immunol. Wilson, N. J. et al. parasites and certain strains of Salmonella spp., Mycobacterium bovis and Mycobacterium tuberculosis129,130. Nasal mucosal cells comprise CD8+ T cells, CD4+ T cells, myeloid cells, innate lymphoid cells, B cells, double-negative T cells, granulocytes, CD117+ cells, and plasma cell populations165. These results are inconsistent with the original idea of Th lineage stability and provide new possibilities for disease treatment aimed at inducing particular Th subsets to modulate the immune response against pathogens or to control detrimental immunity76,77,80. Kuus-Reichel, K. et al. 6. Nat. 17, 665678 (2017). Extensive research has focused on deciphering the role of ILCs to ensure the maintenance of tissue homeostasis and immune protection11,18. & Kaveri, S. V. Passive serum therapy to immunomodulation by IVIG: a fascinating journey of antibodies. 6, 263ra158 (2014). Therapeutic cancer vaccines that contain self- or nonself-patient tumor lysates, viral vectors, mutated tumor proteins or peptides, among other types206 administered in the presence of adjuvants can activate the immune system to induce antitumoral responses207. J. Immunol. Allergy Clin. Researchers are developing more stable and durable vaccines. The development of new technologies to better track the locations and activities of distinct microbial populations is essential to elucidate host-microbe interactions, through which other systems, such as the nervous system, seem to play important roles2,122,123,124,125. Clin. The shared and contrasting roles of IL2 and IL15 in the life and death of normal and neoplastic lymphocytes: Implications for cancer therapy. You can continue to rely on Advances in Immunology to provide you with critical reviews that examine subjects of vital importance to the field through summary and evaluation of current knowledge and research. volume18,pages 805828 (2021)Cite this article. ISSN: 0065-2776. . Sukari, A., Nagasaka, M., Al-Hadidi, A. Advances in Immunology Research - About Journal - Emres Publisher Sci. The endpoint is a significant decrease in nave T cells, which reduces the diversity of the T-cell antigen receptor (TCR) repertoire and culminates in disrupted T-cell homeostasis178. J. Immunol. The generation of knockout mice (in which mice lack Ig genes) and further crosses with transgenic mice carrying human antibody sequences led to the generation of mouse strains that were able to produce fully human mAbs229,230. After the interaction, PRRs trigger the expression of costimulatory molecules and activate important signaling pathways to induce the activation of innate and adaptive immune cells. CAS Google Scholar. 35, e149 (2020). The development of new specialized equipment and immunological techniques, genetic approaches, animal models, and a long list of monoclonal antibodies, among many other factors, are improving our knowledge of this sophisticated system. Gomes-Silva, D. & Ramos, C. A. Nature 388, 394397 (1997). Semin. 13, 666678 (2013). Immunol. However, the immunogenicity of these vaccines must be improved, and other problems need be avoided, such as the potential deleterious effects of integrating vaccine sequences into cells324. David, T., Ling, S. F. & Barton, A. Genetics of immune-mediated inflammatory diseases. Licona-Limn, P., Arias-Rojas, A. Immunol. Genet. R. Soc. 62, 4553 (2020). Sabado, R. L., Balan, S. & Bhardwaj, N. Dendritic cell-based immunotherapy. Moreover, immunization of pregnant women may help to enhance neonatal protection against several pathogens321. Rev. Numerous other attempts to use microorganisms to cure inflammatory illnesses (Crohns disease, ulcerative colitis, etc.) Knochelmann, H. M. et al. Snchez-Ramn, S. et al. Nat. The integration of these endogenous signals is essential for the maintenance of tissue homeostasis, but dysregulation of ILC responses leads to inflammation and disorder12,20. Opin. Most allergic diseases have allergy-related traits such as asthma, with the strongest association mapped to chromosome 17q21. Curr. & J, L. Virus interference. 15, 809821 (2019). Phytopathol. Nat. Although immunotherapy can be used for many diseases (infections, autoimmune diseases, macular degeneration, allergic diseases, etc. Immunol. 10, 45 (2018). Eur. Lond. Oncol. Mazmanian, S. K., Liu, C. H., Tzianabos, A. O. & Kampmann, B. 9, 2936 (2018). Sander I. van Kasteren, Jacques Neefjes & Huib Ovaa, Nicolas Jacquelot, Cyril Seillet, Gabrielle T. Belz, Nicholas A. Maskalenko, Dmitry Zhigarev & Kerry S. Campbell, Gregory F. Sonnenberg & Matthew R. Hepworth, Kamir J. Hiam-Galvez, Breanna M. Allen & Matthew H. Spitzer, Willem J. M. Mulder, Jordi Ochando, Mihai G. Netea, Natalie K. Wolf, Djem U. Kissiov & David H. Raulet, Cellular & Molecular Immunology Induction of cell death by apoptosis. Rev. Critical role for the chemokine receptor CXCR6 in NK cell-mediated antigen-specific memory of haptens and viruses. This outcome is especially important for pathogens with high variability (such as the influenza virus). The editors encourage submission of original research findings from all areas within the broad field of immunology from all model organisms . 19, 402414 (2019). Klin. Al-Mousa, H. & Al-Saud, B. Simoni, Y. et al. Allergy Clin. Holm, T. L., Nielsen, J. 116, 2424224251 (2019). These innate cells have been considered to be tissue-resident cells, but recent studies suggest that ILCs can migrate through the lymphatic system during homeostasis or enter into the circulation upon infection and inflammation6,12. A., Barlow, J. L. & McKenzie, A. N. J. Innate lymphoid cells-how did we miss them? The World Health Organization (https://www.who.int/topics/vaccines/en/) argues that anti-vaccine movements can roll back all the achievements thus far in this field and have cited this issue as one of the main challenges to be resolved. Langerhans, P. Ueber die Nerven der menschlichen Haut. 14, 907917 (2018). The induction of Th17 cell maturation by segmented filamentous bacteria has also been reported121. Developing Covid-19 vaccines at pandemic speed. 9, 1768 (2018). Approaches and advances in the genetic causes of autoimmune disease and their implications. PubMed Central 7. Schlom, J. et al. Immunity 46, 148161 (2017). A. Mol. Angelidou, A. et al. The journal is a member of the Committee on Publication Ethics (COPE). Arrieta, M.-C., Walter, J. Editors' Picks: May Highlights from the AACR Journals 3e mmoire. Front. 194, 31163126 (2015). Investig. PubMed Central Cancer Immunol. Rajalingam, R. The impact of HLA class I-specific killer cell immunoglobulin-like receptors on antibody-dependent natural killer cell-mediated cytotoxicity and organ allograft rejection. The safety and potential adverse long-term effects are also being assessed. In terms of innate immunity, aging results in a decreased number of circulating monocytes and dendritic cells, reduced phagocytic properties of macrophages and neutrophils, and impaired antigen presentation by dendritic cells179. 3.543 Impact Factor. Opin. Advances in Immunology - SCI Journal Interferon (IFN) was described in 1957 by Isaacs and Lindenmann252. Exp. To obtain approval for the use of other elements from incipient fields, such as the use of different types of nanostructures, either alone or in combination with other immunotherapies, it is important to resolve certain issues. 75, 14 (2012). In 1997, Medzhitov et al. Science 326, 16941697 (2009). Paradoxically, there are people who doubt the beneficial effects of vaccines, and they are putting the health of their own children and society in general at risk327. U.S.A. 107, 1475114756 (2010). Currently, five different ILCs are defined on the basis of their transcription factor expression, different cytokine production and/or developmental patterns6: natural killer (NK) cells (discussed below), lymphoid tissue inducer cells (LTis) and three subsets of helper-like ILCs (ILC1s, ILC2s, and ILC3s), which are considered to be the innate counterparts of T helper (Th) 1, Th2, and Th17 cells, respectively. Des. MAbs 10, 183203 (2018). Impact Factor Cited Half-Life Immediacy Index Journal Citation Indicator (JCI) . Furthermore, complete cure and partial remission outcomes have also been observed. As mentioned above, aging also generates a reduction in the T-cell and B-cell receptor repertoire due to the accumulation of senescent or exhausted lymphocytes, together with a decrease in the number of circulating nave T and B cells178,179. Many years ago, the only adjuvant authorized for vaccines was aluminum hydroxide (alum), but currently, several adjuvants are on the market325. U.S.A. 1417, 104115 (2018). Microb. 9, 791 (2018). N. Engl. Immun. Posch, W., Lass-Flrl, C. & Wilflingseder, D. Generation of human monocyte-derived dendritic cells from whole blood. & Warrington, R. Primary immunodeficiency. The rest of the associated loci involved in the pathogenesis of allergy highlight the importance of the Th2 responses (STAT6 (signal transducer and activator of transcription 6), TSLP (thymic stromal lymphopoietin), BCL6 (B-cell lymphoma 6 protein), IL1RL1 (interleukin 1 receptor-like 1), IL33 (interleukin 33), GATA3 (trans-acting t-cell-specific transcription factor binding protein 3)); innate immunity (TLR1/6/10 (Toll-like receptor 1/6/10)); TGF-signaling (LRRC32 (leucine rich repeat-containing 32), SMAD3 (mothers against decapentaplegic homolog 3)); T-cell (IL2 (interleukin 2), PTGER4 (Prostaglandin E Receptor 4)) and T regulatory box (LRRC32 (leucine rich repeat-containing 32), IL-2, NFATC2 (nuclear factor of activated T cells 2), FOXA1 (forkhead box A1))164. New generations of CARs, including the CD3 subunit together with other signaling domains, such as CD28, CD134, CD137 (41BB), CD27, and ICOS, or combinations (CD3 , CD28, and CD134)301, have been developed in the second and third generations of CARs to improve several aspects, such as the activation, proliferation and survival of CAR T cells. Rev. It is crucial to find validated biomarkers (with predictive and/or prognostic value) that can help to stratify or select patients for the best immunotherapy. 38, 10591074 (2015). An ISSN is an 8-digit code used to identify newspapers, journals, magazines and periodicals of all kinds and on all media-print and electronic. Immunity 52, 5581 (2020). The development of universal cells, for example, in the case of CAR T-cell therapy, would increase the number of patients who could benefit from this treatment at thus reduce the costs. & Lazar, G. A. Belkaid, Y. Immunol. U.S.A. 106, 19151919 (2009). Detailed coverage of this topic is beyond the scope of this review, and we refer the reader to recent reviews that provide more information on the biology of human32 and mouse33,34 ILCs. CAS Psychiatry 6, e774 (2016). Cytotoxicity mediated by NKcells. Run Fang, . 8, 639646 (2007). Rappuoli, R., Pizza, M., Del Giudice, G. & De Gregorio, E. Vaccines, new opportunities for a new society. Krre, K., Ljunggren, H. G., Piontek, G. & Kiessling, R. Selective rejection of H2-deficient lymphoma variants suggests alternative immune defence strategy. Genome Med. In particular, minor histocompatibility antigens, which are peptides derived from allelic variants of normal cellular proteins, presented by class I or II MHC antigens induce cellular immune responses in HLA-matched individuals who lack the same allelic variant150. Joo, C., Negi, V. S., Kazatchkine, M. D., Bayry, J. & Coffman, R. L. Two types of murine helper T cell clone. Immunol. In addition, immunization of mice with bacillus Calmette-Gurin (BCG, the tuberculosis vaccine) induces T cell-independent protection against secondary infections by Candida albicans, Schistosoma mansoni or influenza virus90,91,92,93. 8, 1751 (2017). In cases for which long-lasting tolerance is acquired, therapy may be discontinued. Nat. Human natural killer cells mediate adaptive immunity to viral antigens. More studies are centered on understanding how to manipulate bacterial colonies, the discovery of therapeutic molecules, nutrient competitions, etc., that are required for successful application. 129, 434440 (2012). Cell Press: Trends in Immunology 1112, 255280 (2018). Although not without limitations, these techniques provide a much better picture of the whole immune system than individual and independent approaches. Although the basis of immune regulation was suggested centuries ago, regulatory T cells were described by Sakaguchi et al. Immunopathol. Adjunct immunotherapies for the management of severely Ill COVID-19 patients. Larsen, S. B., Cowley, C. J. The gut microbiota influences blood-brain barrier permeability in mice. Med. 42, 4360 (2020). Okazaki, T. & Honjo, T. PD-1 and PD-1 ligands: from discovery to clinical application. J. Immunol. Only three years later, George Snell described the MHC, which carries the histocompatibility genes, and one decade later, Jean Dausset described the human leukocyte antigen (HLA); each of these scientists was recognized with the Nobel Prize in Physiology and Medicine148. Methods Mol. Latest volume; All volumes; Chapters in press; . Development, cytokine profile and function of human interleukin 17-producing helper T cells. The immunotherapeutic strategies include the following: Targeting inflammatory molecules. & Rosenberg, S. A. Lymphokine-activated killer cell phenomenon. 7, 507516 (2006). Complement activation. Epigenetic programming of monocyte-to-macrophage differentiation and trained innate immunity. Immunol. IL-5 and IL-13 produced by ILC2s induce goblet cell differentiation and the recruitment of eosinophils, basophils, and mast cells22, which are involved in protection against infection by helminths and viruses, but when uncontrolled, these cells drive allergic responses and metabolic disorders. The use of oncolytic viruses (OVs), bacteriophages that selectively infect bacteria, modified pathogens for vaccines or for antitumor immuno-activation, and the manipulation/modification of the microbiota are some of the therapies that are being considered. Immunol. This situation changed because of one of the latest revolutions in antitumor therapy, the development of T lymphocytes that carry a chimeric antigen receptor (CAR) based on a specific antibody directed to a target surface molecule299,300. Allergy Clin. The specificity and the capacity to generate long-lived memory cells are two properties that have been classically used to distinguish innate immunity from adaptive immunity. GWAS for systemic sclerosis identifies multiple risk loci and highlights fibrotic and vasculopathy pathways. You can continue to rely on Advances in Immunology to provide you with critical reviews that examine subjects of vital importance to the field through summary and evaluation of current knowledge and research. Since the first generation of CARs appeared, namely, a chimeric receptor composed of an anti-CD19-specific single-chain variable fragment linked to a transmembrane domain and intracellular signaling domain of the T cell receptor (CD3 chain), researchers started to modify the original design.

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